"NASCAR racing and Slayer have a lot in common. Both are extremely fast, intense and aggressive", said guitarist Kerry King.
The thrash metal giants have lined up a total of 19 dates across the US throughout November and December.
The metal legends have added the new show after their previously-advertised LA date on 30 November sold out in 24 hours.
The concert at Estadio Bicentenario de La Florida is being billed as Slayer's final performance in frontman Tom Araya's native country.
"We want to assure our fans that we’ll get to as many places around the world as possible", says Kerry King.
The thrash metal icons embark on the European leg of their Farewell Tour with Anthrax and Obituary also on the bill.
Watch thrash metal icons Slayer discuss the early days of their remarkable 37-year career in a new video documentary shared online
Legendary death metallers Slayer have announced they will make their exit after playing one final world tour after a career spanning four decades