Abel Tesfaye will also unveil an expansive collaboration with Japanese Kaikai Kiki artist, MR. to celebrate the moment.
The song now spent 88 weeks on the Hot 100, breaking the previous record set by Imagine Dragons with 'Radioactive'.
The dynamic new version adds another two minutes to the regular single cut.
The award is is presented annually to the world’s best-selling single of the year across all digital formats.
During the under 15-minute performance, he played songs from throughout his career including 'Save Your Tears' and 'Blinding Lights'.
The widely-acclaimed, 14-track release topped MRC Data’s year-end report in North America.
Recently revealed as iHeartRadio's most played song in North America, 'Blinding Lights' celebrates its first anniversary with this new remix.
Titled ‘A Starboy Is Born’, the new episode is set to air in the US on TBS on Monday, 4 May.
The original version of the song is taken from the Toronto artist’s, AKA Abel Tesfaye, recent album After Hours.
Last night's episode was presented by none other than 007 himself, Daniel Craig.
As yet, though the artist is still to reveal the release date for the new record, which is the follow-up to 2016's 'Starboy'.
The Weeknd shared the official new music video for his hit single ‘Blinding Lights’, picking up where his ‘Heartless’ video left off.