Bishop Gunn, Blackberry Smoke and Dirty Honey will also be appearing at selected dates.
Discussing the band's upcoming 12th studio record, the guitarist says they already have a “bunch of songs” in the bag.
The new festival is set to debut on 11-13 October at the Great Stage Park in Manchester, Tennessee.
The festival will also feature Disturbed, Shinedown, Steel Panther, Bush and other notable acts.
The Grammy-winning 12-piece fronted by Derek Trucks and Susan Tedeschi have recorded 11 new songs for the set, once again at their own Swamp Raga home studio.
Featuring the timeless classics ‘Free Bird’ and ‘Sweet Home Alabama’, ‘Skynyrd’s Innyrds’ is a one-stop collection of Southern rock brilliance.
Blackberry Smoke provide support for the European dates with Status Quo taking over in the UK.
The rising Nashville roots-rockers played on a Ramblin' Man Fair bill also including The Cult, Halestorm and Blackberry Smoke.
The acclaimed Southern rockers have a formidable live reputation and six albums under their belt to date.
Ramblin’ Man Fair continued for Day Two, this time it was prog and blues feast while the main stage played host to Blackberry Smoke, Halestorm and The Cult.
The Nashville-based quartet will be sharing the 2018 festival's Planet Rock Main Stage with The Cult, Blackberry Smoke, Halestorm and more.
Alice Cooper has united again with the members of his band of the early 1970s for songs on what will be his 27th studio album.