The tour kicks off April 9 in Las Vegas, Nevada.
Dave Mustaine said, "Tour rehearsals just began, and we cannot wait to start crushing North America.”
Billed as ‘The Metal Tour Of The Year’, Trivium and In Flames will also play in support on the extensive US trek.
The bands were forced to call off their 2020 North American run with Trivium and In Flames due to lockdown restrictions.
The band's next record will be the long-awaited follow-up to 2016's celebrated 'Dystopia'.
Both titles are set for release through Craft Recordings on 5 June.
The epic 55-city tour will stretch across summer and fall, kicking off on 12 June in Bristow, VA and wrapping on 13 November in Reno, NV.
The tour is in support of Morton's solo album, 'Anesthetic', out now on Spinefarm Records.
Chris Adler of Lamb Of God has been confirmed as the drummer on the forthcoming 15th studio album by Megadeth.