This year's event will mark country star and 'American Idol' host Bryan's debut as host of the CMA Awards.
Chris Stapleton and Eric Church top the list of nominations with five each.
Winners will be determined in a final round of voting, and the awards ceremony itself takes place on November 10.
The new No.1 extends Church's span of airplay chart-toppers to over nine years, since “Drink in My Hand” in 2012.
'Soul' enters Billboard's Top Country Albums at No.2, a week after 'Heart' debuted at No.3.
The taped concert will feature live performances from the iconic Grand Ole Opry in Nashville in front of a reduced capacity audience.
The 55-city tour will kick off in mid-September, with dates stretching all the way to May 2022.
The full line-up features 29 performing artists in total, including show hosts Keith Urban and Mickey Guyton.
The announcement is part of the national campaign 'It’s Up to You,' which stresses the importance of getting a Covid vaccine.
The track appears on Church’s forthcoming album ‘Heart & Soul’ out April 23.
The ceremony, which honors the best in country music, broadcasts live from Nashville on April 18.
On Sunday, the country star delivered a triumphant performance with Jazmine Sullivan at Super Bowl LV.
The country hero and current CMA Entertainer of the Year wrote the track himself.
C2C was due to take place in March, and will now return over the weekend of March 11-13, 2022 in London, Glasgow and Dublin.
The rare, collaborative performance will mark the event’s first since 2006.