The band's much-anticipated new album, 'Give Me The Future' is set for release on February 4.
The campaign is designed to encourage gig-goers to support grassroots venues close to home.
Knopfler joins Ellie Goulding, Dan Smith of Bastille, Justin Young of the Vaccines, and Ralph McTell in the role.
The London shows will take place around the staging of next year’s BRIT Awards, which will be held at The O2 in London on February 8.
Ticket sales for the event begin Friday, December 10.
The 'Revive Live' campaign was launched last summer in a bid to help UK grassroots venues survive post-coronavirus.
International artists whose videos also took prizes include Lil Nas X, Normani and Megan Thee Stallion.
The new shows are in support of the band's new album, 'Give Me The Future', set for release on February 4.
The band's new album will be out on February 4, 2022 - and it "takes us into a sci-fi wonderland free from restrictions."
Other British winners include Pete Glenister, Becky Hill, MNEK, Steve Mac, and Dan Smith of Bastille.
The new clip was directed by Balázs Simon and combines ground-breaking animation with live action shots filmed in Serbia.
A modernist feminist classic, the film of the same name provided the inspiration for Bastille's latest.
The duo covered the track for Griff's on-going YouTube series, 'Against The Clock'.
Streaming from London's Wembley Arena on August 15, the 90-minute special will be hosted by BBC Radio 1's Greg James and Clara Amfo.
The new song also features in the Jeep brand's 'Life Electrified' campaign, starting today.