The emerging rocker previously made his US TV debut when he played a pair of tracks on 'Jimmy Kimmel Live' in March.
The new track features on the fast-rising outfit's upcoming full-length album 'Fever Dream' out 26 July via Republic Records.
The much-acclaimed album was named after Malcolm Gladwell’s 2000 pop-sociology classic in which he explored how minor movements and behaviors can proliferate.
The Queen of Pop also indulged Fallon in a cha-cha lesson, inviting the entire studio audience to have a dance with her.
In the clip, Nick Jonas takes on vocal lead as Fallon snaps on a Casio keyboard and taps out the beat on a wood block.