The Las Vegas quartet took the honours with their much-acclaimed trio of singles, ‘Believer,’ ‘Thunder,’ and ‘Radioactive’.
The ceremony which aired on Fox was hosted by rapper T-Pain and featured performances by Halsey, Garth Brooks and Kacey Musgraves, among others.
The revelatory ‘Smoke + Mirrors’ took Imagine Dragons up another level, revealing them as a “tightly focussed rock juggernaut” hitting greatness.
'Radioactive' also features on the band's classic 'Night Visions' album, set for vinyl reissue on 22 February.
Filmed in Las Vegas, the video features dancer Autumn Miller with choreography by Marissa Osato.
The widely-acclaimed album won Billboard's prestigious Top Rock Album Of The Year award in 2014.
The band will perform live from Treasure Island, located in the San Francisco Bay.
Camila Cabello also narrowly beat Taylor Swift, Drake and Imagine Dragons to win Best International Artist.
Imagine Dragons reflect on the 10-year journey to their fourth studio album 'Origins', with this behind-the-scenes video.
'Origins' was conceived as a sister record to the band's 2017 album 'Evolve' and continues with its predecessor’s sonic explorations.
The much-anticipated 'Origins' is due for release on 9 November through KIDinaKORNER/Interscope Records.
The new video has been directed by Ariana Grande and Kendrick Lamar film-maker Dave Meyers.
The band are also releasing a digital deluxe version of current studio album, 'Gravity', on 26 October.
Imagine Dragons have also recently announced the release of their fourth album 'Origins' due out on 9 November.
'Origins' is the follow-up to 'Evolve', which has been certified gold in the UK and double-platinum in the US.
This year's fan-voted AMAs will air live on ABC on 9 October from the Microsoft Theater in Los Angeles.